acute intracerebral hemorrhage
Conditions
Interventions
Medication of perindopril
controlgroup
Sponsors
Shonan Kamakura General Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Acute intracerebral hemorrhagic patients 1) who admit within 72 hour from onset, 2) who initiate nasal-gastric tube feeding within two days dorm admission due to altered mental state, or severe dysphagia, 3) whose age is 20 or more and less than 85 at admission, 4) whose systolic blood pressure is more than 140 mmHg,or diastolic blood pressure is more than 90 mmHg on admission 5) and whose premorbid modified Rankin scale is 2 or less.
Exclusion criteria
Exclusion criteria: 1) Patients who died within 48 hours from admission, 2) Patients whose Japan coma scale is 3-200 or more, or Glasgow coma scale is 6 or less, 3) Patients who has diagnosed pneumonia before initiating nasal-gastric tube feeding, 4) Patients who has diagnosed malignant hypertension, 5) Patients who has diagnosed congestive cardiac failure with NYHA of 3 or more, 6) Patients who has took angiotensin converting enzyme inhibitor drugs, 7) Patients who are ineligible for any other reason in the opinion of the investigator.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Prevalence of aspiration pneumonia in acute phase | — |
Secondary
| Measure | Time frame |
|---|---|
| Modified Rankin Scale at 90 days after stroke onset NIHSS scale at 10days after stroke onset Blood pressure Inflammation parameters Duration of antibiotics use | — |
Countries
Japan
Contacts
Public ContactMasahito Nakazaki
Shonan Kamakura General Hospital Deaprtment of Stroke Treatment
Outcome results
None listed