Periodontitis, Atherosclerosis
Conditions
Interventions
None listed
Sponsors
Okayama University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Patients with lifestyle-related disease: one of following criteria LDL over 140 mg/dl systolic blood pressure over 140 mmHg diastolic blood pressure over 90mmHg fasting blood glucose over 110 mg/dl glycosylated Hemoglobin A over 5.9 % Periodontitis patients:following criteria periodontal probing depth over 4mm at any probing site
Exclusion criteria
Exclusion criteria: A) acute myocardial infarction (within 6 months) B) unstable angina C) severe heart diseases D) Cardiovascular surgery (within 6 months) E) cerebrovascular accidents (within 6 months) F) severe hepatitis or renal disease G) malignant tumors H) port control diabetes I) lipidosis with following conditions a) nephrotic syndrome b) hypothyroidism c) cushing Syndrome d) secondary hyperlipemia according to other diseases J) hyperlipemia according to medicine such as steroids K) perioperative patients L) patients with poor compliance
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Periodontitis: Periodontal probing depth, Blood IgG antibody titer to periodontal pathogens Atherosclerosis: Carotid artery Intima - media thickness, Serum lipid, Blood sugar | — |
Secondary
| Measure | Time frame |
|---|---|
| Body Mass Index, Creatine phosphokinase, White blood cell, Urine occult blood, Pulse wave velocity, High - sensitivity C - reactive protein, Tumor necrosis factor - alpha, Adiponectin | — |
Countries
Japan
Contacts
Public ContactShogo Takashiba
Okayama University Department of Pahophysiology - Periodontal Science, Graduate School of Medicine, Dentistry and Phar
Outcome results
None listed