Efficacy of Helicobacter pylori eradication regimen based on antibiotic susceptibility testing in patients with multiple eradication failures

Efficacy of Helicobacter pylori eradication regimen based on antibiotic susceptibility testing in patients with multiple eradication failures - Efficacy of Helicobacter pylori eradication regimen based on antibiotic susceptibility testing

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000007971

Enrollment

Registered

2012-05-16

Start date

2012-05-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Patients with multiple eradication failures

Interventions

Third line eradication therapy with esomeprazole, amoxicillin, and sitafloxacin Rescue therapy based on antibiotic susceptibility testing

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Patients with past history of peptic ulcer, gastric MALT lymphoma, and early gastric cancer treated by endoscopic resection 2. Patients positive for H. pylori infection 3. Patients with two eradication failures by clarithromycin- and metronidazole-based regimen

Exclusion criteria

Exclusion criteria: 1. Pregnancy 2. Lactation 3. Past history of allergy for the drugs used in this study. 4. Severe other organ dysfunction 5. Patients who are disqualified for the study by their physicians

Design outcomes

Primary

Measure	Time frame
Efficacy of Hp eradication	—

Secondary

Measure	Time frame
Eradication rate of different regimen Frequency of adverse effects	—

Countries

Japan

Contacts

Public ContactYoshihiro Hirata

The University of Tokyo Hospital Department of Gastroenterology

hiratay-int@h.u-tokyo.ac.jp03-3815-5411(33070)

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026