DIC caused by severe burns
Conditions
Interventions
rhTM is administered at a dose of 0.06 mg/kg/day by intravenous drip for 30 minutes. This treatment is replaced once daily for 6 days.
Sponsors
Yokohama City University Medical Center
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Patient who fills everything the following (1)DIC established by JAAM (Japanese Association for Acute Medicine) DIC criteria>=4 (2)Severe burns as underlying diseases which directly caused DIC.(Burn Index>=10). (3)Patient who gives written informed consent.
Exclusion criteria
Exclusion criteria: (1)Patients aged < 15 years. (2)Patients showing intracranial, pulmonary or gastrointestinal hemo- rrhage. (3)Patients with a history of hypersensitivity to rhTM. (4)Pregnancy or possibly pregnancy. (5)Other patients judged to be inappropriate at the discretion of investigators.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Mortality in ICU (the interrelation between DIC remission rate and 28-day survival rete). | — |
Secondary
| Measure | Time frame |
|---|---|
| Mortality Course of DIC score Clinical symptom Blood clotting test Inflammatory marker APACHEII HMGB1 Adverse events | — |
Countries
Japan
Contacts
Public ContactYasushi Yamamoto
Yokohama City University Medical Center Critical Care and Emergency Medical Center
Outcome results
None listed