Depression
Conditions
Interventions
Adjunctive acetaminophen therapy for Major Depression
Sponsors
Oizumi Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1,Patients with major depressive disorder (DSM-4) 2,20 to 80 years of age, were recruited. 3,They were required to show no remarkable change of symptom more than 4weeks under the same medications. Patients who showed less than 20% improvements in the Montgomery-Asberg Depression Rating Scale (MADRS) from screening to baseline were included to the study.
Exclusion criteria
Exclusion criteria: 1,Having a serious physical disease.. 2,The presence of previous history of side effects or allergy about Acetaminophen 3,Past history of asthma 4,Past history of heart disease 5,Past history of upper gastrointestinal disease such as gastritis 6,Blood disease 7,Bleeding tendency 8,Liver disease 9,Renal disease 10,Heavy drinker 11,Malnutrition 12,Manic-depressive illness 13,Epilepsy 14,More than 5 points of suicidal thoughts MADRS 15,The presence of psychotic symptom 16,There is no therapeutic response to antidepressants for more than three drugs in the past 17,Pregnant or Breast-feeding 18,Those taking anticoagulants such as Warfarin, Those taking thiazide diuretics, quinolone antibiotics, lithium, carbamazepine, phenobarbital, phenytoin, primidone 19,Those already taking the medicines that contain acetaminophen
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Montgomery-Asberg Depression Scale (MADRS) | — |
Countries
Japan
Outcome results
None listed