Head and neck cancer
Conditions
Interventions
EPA-enriched oral nutrition of 2 packs and oral nutrition with EHA of 250ml was taken 6 to 7 weeks duraing neoadjuvant chemotherapy.
oral nutrition with EHA of 250ml was taken 6 to 7 weeks duraing ne
Sponsors
Juntendo University school of medicine
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1.histologically daiagnosed SCC 2.patients had untreatement head and neck squamous cell carcinoma who needs neoadjuvant chemotherapy 3. ECOG PS of 0, 1 or 2 and the patients who can attend a hospital as a outpatient 4.Written informed consent 5.Sufficient oral or enteral intake 6.Confirmed by the following data white blood cell count 3000-9000/mm3. platelet count over 100,000/mm3. hemoglobin count over 9.0g/dl. serum creatinine below 1.2mg/dl. creatinine clearance over 60 ml/min
Exclusion criteria
Exclusion criteria: 1.with incurable other cancer 2.with obvious infectious disease 3.Uncontrollable diabetes mellitus 4.oral administration of steroid 5.with cardiac, liver, or renal failure 6.with allergy of milk and soybean 7.pregnant, lactating women or women of childbearing potential 8.with chronic inflammatory disease 9.lack of agreement 10.incidence of cerebral hemorrhage or subarachnoid hemorrhage within 1 month before registration 11.oral administration of EPA before registration
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| transition of nutritional condition and inflammatory reaction. | — |
Secondary
| Measure | Time frame |
|---|---|
| length of hostpitalization adverse event rate of completion for radical therapy survival rate | — |
Countries
Japan
Outcome results
None listed