Chronic respiratory failure patients with pulmonary arterial hypertension
Conditions
Interventions
infusion by saccharatedferric oxide
Sponsors
Osaka City General Hospital Department of Respiratory Medicine
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1.Chronic respiratory failure patients 2.Less than Hb 16mg/dl 3.Lower than ferritin level 500ng/ml 4.TR -PG level is more than 32torr in heart ultrasonography findings 5.Age is 60 years old or older 6.Patients receive enough explanation about this study, and patients who provide their written informed consent to participate in this study.
Exclusion criteria
Exclusion criteria: 1.Patient's fever is 38 degrees or more within one week before screening test 2.Patients complicated with active tuberculosis and atypical mycobacterial disease 3.Patients with active respiratory tract infection in chest Xp or clinical examination 4.Patients with active heart failure with the hemostatic findings in chest Xp **But, we make it possible to conduct a screening test after hemostatic findings disappeared in case that recognized hemostatic findings in chest X-rays. 5.Patients with pneumothorax in chest Xp 6.Patients with pleural effusion that drainage needs 7.Patients with history of hypersensitivity with iron preparation formulation 8.Patients who are complicated with apparent hepatic cirrhosis or active hepatitis 9.Patients with history of paroxysmal nocturnal hemoglobinemia 10.Patients with apparent renal failure 11.The patients in acknowledgment of exacerbation with existing illness within one month from screening test 12.A pregnant woman or the patients with the possibility to become pregnant and nursing patients 13.In addition, the patients whom doctor attending judged to be inadequate as a study candidate
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| TR-PG level by the heart ultrasonography | — |
Secondary
| Measure | Time frame |
|---|---|
| PaO2 level, reticulocyte count, NT-pro BNP level, hematocrit, mean concentration hematocrit (MCH), mean corpuscular hemoglobin concentration (MCHC) | — |
Countries
Japan
Contacts
Public ContactMitsuhiro Sumitani
Osaka City Gerenal Hospital Respiratory Medicine
Outcome results
None listed