Major depressive disorder
Conditions
Interventions
Comparison of genetic differences among young-onset (onset below 40 aged), middle- or senile-onset (onset above 40 aged) depressive and healthy control patient groups.
Comparison of regional brain blo
Sponsors
Gunma University Graduate School of Medicine
Division of neuropsychiatry, department of neuroscience, Yamaguchi university graduate school of medicine
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: This study includes major depressive patients and age- and gender-matched healthy controls, in accordance with following inclusion criteria. 1) Major depressive patients are detected in accordance with Diagnostic and Statistical Manual of Mental Disorder (DSM-IV-TR) 2) Inpatient and out-patient 3) Diagnostic using Mini-International Neuropsychiatric Interview (MINI) 4) Above 50 aged 5) Major Depressive Disorder, Single Episode and multiple episode 6) Major Depressive Disorder with melancholia 7) The patients with above 18 points using Structured Interview Guide for the Hamilton Depression Rating Scale (SIGH-D) 8) The remission period is detected in accordance with below 8 points by Structured Interview Guide for the Hamilton Depression Rating Scale(SIGH-D) 9) Patents with and without drug administration
Exclusion criteria
Exclusion criteria: This study excludes major depressive patients and age- and gender-matched healthy controls, in accordance with following exclusion criteria. 1) The subjects with contraindication for MRI, i.e., heart pacer user 2) The subjects with significant physical illness 3) The pregnant or lactating women 4) The Patents during involuntary admission 5) The Patents during emergency admission 6) The patients, whom medical doctor exclude as impropriety 7) The healthy controls, who has a the first-degree relatives with psychiatric disorders 8) The patients with below 23 points of MMSE
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Assessments by Near Infra- Red Spectoroscopy, 123I-IMP-SPECT, 3T-Magnetic Resonance Image (MRI), gene and blood sampling to compare among young-onset (onset below 40 aged), middle- or senile-onset (onset above 40 aged) depressive patient and healthy control groups. | — |
Secondary
| Measure | Time frame |
|---|---|
| Assessment by prognosis after treatment, and atherosclerotic factors. | — |
Countries
Japan
Contacts
Public ContactKosuke Narita
Gunma University Graduate School of Medicine Psychiatry and Neuroscience
Outcome results
None listed