The effect of nutritional therapy for subclinical hepatic encephalopathy in liver cirrhosis;preliminary multicenter study in Japan-

The effect of nutritional therapy for subclinical hepatic encephalopathy in liver cirrhosis;preliminary multicenter study in Japan- - Nutritional therapy for subclinical hepatic encephalopathy

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000007804

Enrollment

Registered

2012-04-21

Start date

2010-08-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Viral Liver Cirrhosis

Interventions

Diet group: Energy 30-35 kcal/kg Protein 1.0-1.2 g/kg Aminoleban EN group: The total calorie and protein is estimated as the same as diet group and it includes two sachets of Aminoleban EN.

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1)Viral liver cirrhosis patients who are younger than seventy years old 2)More than two abnormal NP-tests out of four tests 3)Obtained informed consent 4)Post-operative HCC patients who are judged as adequate for this trial 5)Without obvious HE

Exclusion criteria

Exclusion criteria: 1)History of HE 2)Take or will take the treatment for THIPS and esophagogastric varices in the examination period. 3)Impossible to perform NP-tests 4)Judged unsuitable by personal physician

Design outcomes

Primary

Measure	Time frame
The primary endopoint is to evaluate the ratio of improved SHE.	—

Countries

Japan

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026