Effects of exercise on cognitive functions in the elderly adults with mild cognitive impairment: a randomized controlled trial

Effects of exercise on cognitive functions in the elderly adults with mild cognitive impairment: a randomized controlled trial - A randomized control trial for preventing decline of cognitive functions in the elderly with MCI

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000007749

Enrollment

308

Registered

2012-04-15

Start date

2012-01-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

mild cognitive impairment

Interventions

Intervention group: Supervised exercise for 1 year Control group: Lecture about disease and health (3 times per year)

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1) Elderly people, aged 65 over and living in Obu city, having health check from Aug in 2011 to Feb in 2012. 2) Fullfilled Peterson's criteria (a: cognitive function is 1.5 SD or more below the normative values; b: score of more than 24 on the Mini-Mental State Examination; c: not diagnosed dementia; d: being independent in activity of daily living; e: having a complain of subjective memory problem) 3) Being agreed with participation in the study

Exclusion criteria

Exclusion criteria: 1) Having serious or unstable illnesses 2) History of psychiatric disease 3) Receiving of anti-Alzheimer drugs 4) Geriatrics Depression Scale > 5 5) Needing long-term care

Design outcomes

Primary

Measure	Time frame
Cognitive function: Wechsler Memory Scale-Revised Logical Memory , Rey Auditory Verbal Learning Test, word list memory	—

Secondary

Measure	Time frame
Cognitive function: Digit span, modified digit symbol substitution test, verbal fluency, modified trail making test, flanker test, backward counting Brain volumetry: MRI Brain function: FDG PET and fNIRS Physical function: muscle strength, gait analysis, six minutes walk, balance control Activity: Tokyo Metropolitan Institute of Gerontology Index of Competence, Life-space assessment, Physical Activity Scale for the Elderly, pedometer Health related characteristics: apathy, pain, fall, QOL, Pittsburgh Sleep Quality Index, fall efficacy scale, gait efficacy scale, social activity	—

Measure

Time frame

Cognitive function: Digit span, modified digit symbol substitution test, verbal fluency, modified trail making test, flanker test, backward counting Brain volumetry: MRI Brain function: FDG PET and fNIRS Physical function: muscle strength, gait analysis, six minutes walk, balance control Activity: Tokyo Metropolitan Institute of Gerontology Index of Competence, Life-space assessment, Physical Activity Scale for the Elderly, pedometer Health related characteristics: apathy, pain, fall, QOL, Pittsburgh Sleep Quality Index, fall efficacy scale, gait efficacy scale, social activity

—

Countries

Japan

Contacts

Public ContactShimada Hiroyuki

National Center for Geriatrics and Gerontology Department for Research and Development to Support Independent Life of Elderly

jiritsu@ncgg.go.jp0562445651

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026