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Phase I study to evaluate the safety and efficacy of resveratrol in enhancing the function of natural killer cells

Phase I study to evaluate the safety and efficacy of resveratrol in enhancing the function of natural killer cells - Safety and efficacy of resveratrol in enhancing NK activity

Status
Active, not recruiting
Phases
Phase 1
Study type
Interventional
Source
JPRN
Registry ID
JPRN-UMIN000007690
Enrollment
20
Registered
2012-04-09
Start date
2012-05-01
Completion date
Unknown
Last updated
2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

immune insufficiency, hematologic malignancy, solid tumor

Interventions

Intake period of Transmax resveratrol, 28 days
observation period, 15 days
control period, 42 days Control period, 42 days
intake period of Transmax resveratrol, 28 days
Intake period of Melinjo resveratrol, 28 days
intake period of Melinjo resveratrol, 28 days

Sponsors

Kanazawa University Hospital
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: No subjective symptom, drinking three times or less a week, and normal liver and renal function that has been confirmed in a medical examination within one year.

Exclusion criteria

Exclusion criteria: Any of the following: currently receiving a drug therapy, currently having chronic diseases such as heart, lung, kidney, gastrointestinal, and inflammatory diseases, suffering from invasive cancer within five years, suffering from non-invasive cancer within a year, and a history of smoking within one year.

Design outcomes

Secondary

MeasureTime frame
Influence of resveratrol in the expression of NK related receptors on NK cells. Influence of resveratrol in the NK cell activity.

Primary

MeasureTime frame
Resveratrol related toxicity during 12 weeks after the start of oral administration of resveratrol

Countries

Japan

Contacts

Public ContactAkiyoshi Takami

Kanazawa University Hospital Division of Transfusion Medicine and Department of Hematology and Oncology

takami-knz@umin.ac.jp076-265-2017

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026