Hypertensive patients with coronary arteries disease.
Conditions
Interventions
Olmesartan Group
Non- Olmesartan Group
Sponsors
Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: (1)Patient between 20 and 90 years old, with hypertension (2) Patients with coronary stenosis or coronary artery occlusion undergoing PCI (3) Patients who have a de novo lesion to be treated bare-metal stent implantation. (4)Patient who has agreed to undergo all clinical follow ups listed in the present protocol. (5)Patients who has agreed to conditions after receiving an explanation about the contents of the present clinical study and who has signed the consent form approved by the ethical review board at each study site.
Exclusion criteria
Exclusion criteria: (1) Patients who had cerebral accident in the past 12 weeks (2) Patients with acute ST-segment elevation myocardial infarction (3) Old myocardial infarction. (4) Heart failure (LVEF < 45%) (5) Active myocarditis (6) Active pericardium flame (7) A cardiac transplantation(<=6months) (8) Diabetes mellitus (9) Proteinuria (10)Chronic renal dysfunction (eGFR<=60mL/min/1.73 m2) (11) patient who has a bad prognosis's disease from angina (12) Restenosis (13)Chronic total coronary artery occlusion (14) The target lesion is located in or supplied by an arterial or venous bypass graft (15) The target lesion is located in left main trunk. (16) Vessel diameter<2mm (17) Systolic blood pressure is under 100 mmHg (18)Serum creatinine>1.8 mg/dl (19) Serum potassium>5.5mEq/L (20) Altered hepatic function (serum aspartate aminotransferase or alanine aminotransferase >= 3-folds of standard value in each institute) (21)Definite or provisional diagnosis of renal artery stenosis (22)Patients who meet contraindication of vasoconstrictor (23) Severe valvular heart disease (24) Women who are pregnant or lactating, or of child bearing potential, or with a desire to be a parent during the study period. (25)A psychiatric disorder and legal disability (26) Drug or alcohol addiction(<=2years) (27) Other patients judged as being inappropriate for the subjects of the study by investigators
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Stents stenosis rate with optical coherence tomography | — |
Secondary
| Measure | Time frame |
|---|---|
| Target vessel revascularization, changes in high-sensitivity CRP ,changes in angiotensin 2 | — |
Countries
Japan
Contacts
Public ContactHiromasa Otake
Department of Internal Medicine, Kobe University Graduate School of Medicine Division of Cardiovascular Medicine
Outcome results
None listed