Bipolar depression
Conditions
Interventions
Lithium (0.8 mEq/L, 8 weeks), active TMS (double-blind trial, 6 weeks), active TMS (non-blind trial, 2-6 weeks)
Lithium (0.8 mEq/L, 8 weeks), sham TMS (double-blind trial, 6 weeks), active TMS (non-bl
Sponsors
Department of Neuropsychiatry, Kyorin University School of Medicine
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. DSM-IV-TR diagnosis of bipolar disorder, major depressive disorder 2. Aged 20-70 y/o 3. HAMD 17 score ≥ 18 4. Current episode duration ≤ 3 y
Exclusion criteria
Exclusion criteria: 1. Rapid cycler type 2. Psychotic episode, OCD, PTSD, eating disorder 3. Previous treatment with ECT, TMS, VNS, DBS, tDCS 4. Pregnancy 5. Personal or close family history of seizure disorder 6. Neurologic disorder, organic brain disease 7. Substance or alcohol dependence 8. Ferromagnetic material in body or close to head 9. Severe metabolic disease, endocrine disease 10. Active suicide idea 11. Taking medications known to lower seizure threshold
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| HAMD 17, HAMD 24, MADRS Severity of depression is rated with these scales every 2 weeks. | — |
Secondary
| Measure | Time frame |
|---|---|
| CGI, YMRS | — |
Countries
Japan
Outcome results
None listed