Treatment of refractory depression using NeuroStar TMS Therapy System and a predictor of the treatment response: a comprehensive, exploratory study through neurobiological, neurophysiological, and neuroimaging approaches

Treatment of refractory depression using NeuroStar TMS Therapy System and a predictor of the treatment response: a comprehensive, exploratory study through neurobiological, neurophysiological, and neuroimaging approaches - Treatment of refractory depression using NeuroStar TMS Therapy System and a predictor of the treatment response: a comprehensive, exploratory study through neurobiological, neurophysiological, and neuroimaging approaches

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000007611

Enrollment

Registered

2012-04-01

Start date

2012-04-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Major depressive disorder

Interventions

Transcranial magnetic stimulation is administered using NeuroStar TMS Therapy System. Stimulation parameter is set at 10 Hz, 120% MT, 4 sec, 3000 pulses, and the stimulation site is the left dorsolate

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. DSM-IV-TR diagnosis of major depressive disorder 2. Aged 20-70 y/o 3. HAMD 17 score; over 18 4. Current episode duration; 3 y 5. Insufficient clinical benefit to 1-4 adequate medication trials in the current episode

Exclusion criteria

Exclusion criteria: 1. Psychotic episode, bipolar disorder, OCD, PTSD, eating disorder 2. Previous treatment with ECT, TMS, VNS, DBS, tDCS 3. Pregnancy 4. Personal or close family history of seizure disorder 5. Neurologic disorder, organic brain disease 6. Substance or alcohol dependence 7. Ferromagnetic material in body or close to head 8. Severe metabolic disease, endocrine disease 9. Active suicide idea 10. Taking medications known to lower seizure threshold

Design outcomes

Primary

Measure	Time frame
HAMD 17, HAMD 24, MADRS Severity of depression is rated with these scales every 2 weeks.	—

Secondary

Measure	Time frame
CGI, YMRS	—

Countries

Japan

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026