Type 2 diabetes mellitus complicated with essential hypertension
Conditions
Interventions
new administration of DPP-4 inhibitor
new administration or loading of sulfonylurea
Sponsors
Kyoto Prefectural University School of Medicine Department of Cardiovascular Medicine
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Eligible outpatients met the following criteria: 1) Hypertensive patients with type 2 diabetes who are treated with ARB. 2) Type 2 diabetic patients taking oral hypoglycemic agents (sulfonylurea) or none with hemoglobin A1c level (JDS) more than 6.1% for at least 2 months.
Exclusion criteria
Exclusion criteria: Patients are excluded from the study if there is any evidence of type 1 diabetes, treatment with insulin, GLP-1 analog, and other hypoglycemic agent except for sulfonylurea, renal failure (serum creatinine: more than 1.5 mg/dl for male, 1.3 mg/dl for female), severe liver dysfunction, pregnancy and past history of diabetic coma within 6 months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| ratio of pro-insulin to insulin, HOMA-beta | — |
Secondary
| Measure | Time frame |
|---|---|
| HbA1c, insulin sensitivity(HOMA-IR), body weight, blood pressure | — |
Countries
Japan
Contacts
Public ContactYamada Hiroyuki
Kyoto Prefectural University School of Medicine Department of Cardiovascular Medicine
Outcome results
None listed