Adult T-cell leukemia/lymphoma
Conditions
Interventions
Treatment of zoledronic acid
Sponsors
Saga University, Faculty of Medicine, Devision of Hematology and Oncology
Karatsu red-cross hospiral
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: a) Confirmation of T-cell with hematological or pathological examination b) positive for anti HTLV-1 antibody c) Acute type, lymphoma type or transformed to acute or lymphoma type from chronic or smoldering type d) Aged 15 to 75 years old e) perfomance status 0-3, PS 4 caused by hypercalcemia is eligible f) No prior chemotherapy or radiotherapy for ATL, except for steroid g) No central nervus system involvement at diagnosis h) Sufficient function of main organ i) No the need for invasive dental treatment j) Written informed consent from a patient. If consciousness disturbance caused by hypercalcemia, it allowed to the acceptance of family
Exclusion criteria
Exclusion criteria: a)History of glaucome b) Uncontrollable diabetes mellitus or administration of insulin c) Uncontrollable hypertension d) Poor cardiac function e) Active infection requiring systemic therapy f) acute hepatitis, chronic hepatitis, liver cirrhosis g) Synchronous or metachronous maliganacy h) Psychological problem i) active dental disease indicating invasive dental treatment j) Systemic steroid treatment k) History of adminisration of intravenous bisphophonate
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| progression free survival in one year | — |
Secondary
| Measure | Time frame |
|---|---|
| progression free hypercalcemia, overall suvival in one year, feasibility for scheduled zoledronic acid | — |
Countries
Japan
Contacts
Public ContactNoriyasu Fukushima
Saga University, Faculty of Medicine Hematology and Oncology
Outcome results
None listed