Explorative trial of suppression effect of preoperative enteral nutrition enrichied with Eicosapentaenoic Acid(EPA) for hypercytokinemia after pancreaticoduodenectomy :a double blinded and randomaized controlled trial

Explorative trial of suppression effect of preoperative enteral nutrition enrichied with Eicosapentaenoic Acid(EPA) for hypercytokinemia after pancreaticoduodenectomy :a double blinded and randomaized controlled trial - Explorative trial of suppression effect of preoperative enteral nutrition enrichied with Eicosapentaenoic Acid(EPA) for hypercytokinemia after pancreaticoduodenectomy :a double blinded and randomaized controlled trial

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000007533

Enrollment

Registered

2012-03-30

Start date

2012-04-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Patients to require pancreaticoduodenectomy

Interventions

enteral nutrition enrichied with Eicosapentaenoic Acid(EPA) enteral nutrition

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: (1)Histologically or clinically diagnosed as pancreaticoduodenal cancer (i.e. pancreas head cancer, biliary cancer, papilla cancer or duodenal cancer) (2)Treated with curative resection (3)Needed to be admitted for a week or more in order to relieve jaundice (4)ECOG performance formans status is 0 or 1 (5)Fulfil all following conditions WBC < 10,000/mm3 Hb > 8.0g/dL Cre < 1.5mg/dl

Exclusion criteria

Exclusion criteria: (1)With poor oral intake (2)With other nutrition therapy (3)Being immunocompromised status or receiving steroids (4)With uncontrolled diabetes mellitus (5)With inflammatory bowel disease (6)With bacterial or viral infection (7)With radiation therapy, chemotherapy or nutrition therapy before registration (8)With psychiatric disorder (9)Possibly pregnant

Design outcomes

Primary

Measure	Time frame
The serum IL-6 value before and after pancreaticoduodenectomy	—

Secondary

Measure	Time frame
The nutrition status after preoperative enteral nutrition enrichied with Eicosapentaenoic Acid(EPA) The cytokine level after pancreaticoduodenectomy CD4/CD8 T lymphocyte balance after pancreaticoduodenectomy The incidence of post-operative infectious complications The incidence of adverse event	—

Countries

Japan

Contacts

Public ContactShuichi Aoki

Shizuoka Cancer Center Division of Hepato-Biliary-Pancreatic Surgery

shuichi1124@msn.com0559895222

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026