Subarachnoid hemorrhage
Conditions
Interventions
Early-intensive group, day 0 to 14 after SAH onset
Minimally-invasive group, day 0 to 14 after SAH onset
Sponsors
Research Institute for Brain and Blood Vessels-AKITA
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Patients were eligible if they were treated with surgical clipping or endovascular coiling for aneurysm.
Exclusion criteria
Exclusion criteria: Exclusion criteria were 1) both good grade (World Federation of Neurological Surgery [WFNS] grade I) and modest bleeds (Fisher CT grade<2), 2) renal disease (creatinine level >2.0 mg/dl) that may limit appropriate fluid loading for volume therapy, and 3) severe left ventricular dysfunction (ejection fraction <35%), intracardiac shunt, permanent cardiac arrhythmia, significant valvular heart disease, or occlusive peripheral arterial disease that may cause inaccurate CO analysis or may restrict hyperdynamic therapy using inotropic pressors.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Occurrence of clinical deterioration caused by DCI. Favorable outcome, defined as the proportion of patients with a modified Rankin score of 0 to 3. | — |
Secondary
| Measure | Time frame |
|---|---|
| Ischemic lesion was assessed by cerebral blood flow using SPECT combined with 3D-SSP analysis (days 7 and 14) and MR diffusion weighted images (days 14 and 21). Occurrences of cardiopulmonary complications, daily fluid intake/loss, and fluid balance calculated daily by subtracting urinary volume from total oral and intravenous intake. Fluid responsiveness using stroke volume variation, central venous pressure or pulmonary artery wedge pressure. Reliability of cardiac output and stroke volume among monitoring devices was also assessed. | — |
Countries
Japan
Contacts
Public ContactTatsushi Mutoh
Research Institute for Brain and Blood Vessels-AKITA Department of Surgical Neurology
Outcome results
None listed