The analysis of mucosal immune responses induced by intranasal administration of an inactivated influenza virus vaccine in human.

The analysis of mucosal immune responses induced by intranasal administration of an inactivated influenza virus vaccine in human. - The detection and analysis of neutralizing antibodies in nasal mucosa induced by intranasal administration of an inactivated whole-virus vaccine (H3N2 virus) in human.

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000007461

Enrollment

Registered

2012-03-07

Start date

2010-10-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Influenza

Interventions

Inactivated whole-virus vaccine of influneza virus (3-fold concentrated HA per dose) in intranasally inoculated twice at 3 weeks interval. Side reaction survey and neutralization, HI, and HA-specific

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Healthy adult volunteers who are interested in the open requirement for our study, and who receive informed consent before this study and agree with our study contents.

Exclusion criteria

Exclusion criteria: 1. Volunteers with a fever at the time of planned vaccination. 2. Volunteers with serious acute diseases. 3. Volunteers considered inappropriate to be inoculated vaccine.

Design outcomes

Primary

Measure	Time frame
Neutralization, HI, and HA-specific antibody titers before and after intranasal vaccination. Survey on side reaction after vaccination.	—

Countries

Japan

Contacts

Public ContactHideki Hasegawa

National Institute of Infectious Diseases Department of Pathology

hasegawa@nih.go.jp03-5285-1111

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026