Evaluation of the changes of quantity and quality of tears by rebamipide sodium instillation

Evaluation of the changes of tears by rebamipide - Evaluation of the changes of tears by rebamipide

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000007429

Enrollment

Registered

2012-03-02

Start date

2012-03-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Dry eye

Interventions

Instillation (rebamipide) Instillation (artificial tear)

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Normal subject (20 persons) without following 1)-4) 2. Aqueous tear deficient dry eye patients (20 persons) with following 1)-3). 3. Evaporative dry eye patients (20 persons) with following 2) and 3). 4. Short BUT type dry eye patients (20 persons) with following 2) who have symptoms not responsible for conventional instillation treatment 1) Schirmer test (I) <= 5mm 2) Tear film breakup time <= 5 seconds 3) Positive vital dye staining of cornea and conjunctiva (Fluorescein, Lisamine green) (more than 3, maximum=9)

Exclusion criteria

Exclusion criteria: Anyone who is considered to be inappropriate for this study (ex. Any allergic history to diquafosol sodium and artificial tear, women who are under pregnant or lactation period)

Design outcomes

Primary

Measure	Time frame
Tear film breakup time, corneal and conjunctival epithelial damage score, tear meniscus radius, Schirmer test(I), spreading velocity of tear film lipid layer, questionnaire(VAS score)	—

Countries

Japan

Contacts

Public ContactNorihiko Yokoi

Kyoto Prefectural University of Medicine Department of Ophthalmology

nyokoi@koto.kpu-m.ac.jp075-251-5575

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026