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A prospective co-hort study about efficacy and safety for sorafenib treatment in patients with advanced hepatocellular carcinoma.

A prospective co-hort study about efficacy and safety for sorafenib treatment in patients with advanced hepatocellular carcinoma. - A prospective co-hort study about efficacy and safety for sorafenib treatment in patients with advanced hepatocellular carcinoma.

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
JPRN
Registry ID
JPRN-UMIN000007427
Enrollment
300
Registered
2012-03-02
Start date
2009-05-01
Completion date
Unknown
Last updated
2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hepatocellular carcinoma

Interventions

None listed

Sponsors

Division of Gastroenterology, Department of Medicine Kurume University School of Medicine
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: The patient who can expect survival more than three months. A case of EOCG performance status 0 or 1. The patient that an effect of the previous treatment, a side effect are not carried over A case (inspection within two weeks before registration) that enough main organ (including marrow, a heart, the liver, the kidney) functions are maintained. More than WBC 2000/mm3 More than 8.5 g/dl of Hb More than Platelet 50,000/mm3 Less than Child-Pugh score seven points Total bilirubin. 2 mg/dl or less There not being the abdominal dropsy that Control is impossible of, hepatic encephalopathy Is less than Creatinine 1.5 mg/dl; or Creatinine Clearance more than 50ml/min Ejection fraction more than 45% (heart trouble merger patient) A PaO2 more than 60 mmHg (chronic lung disease patient)

Exclusion criteria

Exclusion criteria: An infectious disease of the activity (but except the viral hepatitis) An overlap cancer of the activity A past of sensitivity to iodocontrast media A pregnant woman, a nursing girl may be pregnant The case that the medical attendant judged to be inappropriate as an object of the final examination for reasons of others (problem cases such as a patient does not hear instructions or the support of the family not being provided)

Design outcomes

Primary

MeasureTime frame
The primary outcome of this study is the overall survival time.

Countries

Japan

Contacts

Public ContactMasahito Nakano

Kurume University School of Medicine Division of Gastroenterology, Department of Medicine

nakano_masahito@kurume-u.ac.jp0942-35-3311

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026