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The Esophageal Dysfunction Plays a Key Role in the Pathogenesis of PPI-resistant Globus sensation

The Esophageal Dysfunction Plays a Key Role in the Pathogenesis of PPI-resistant Globus sensation - PPI-resistant Globus sensation

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
JPRN
Registry ID
JPRN-UMIN000007417
Enrollment
100
Registered
2012-03-01
Start date
2011-02-01
Completion date
Unknown
Last updated
2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

dyspahgia and/or globus sensation

Interventions

After 4 weeks of treatment with rabeprazole sodium (20 mg daily), the patients were divided into PPI-responsive and PPI-resistant groups. Then we investigated oesophageal motility in the PPI-resistant

Sponsors

Kawasaki Medical School
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: A total of patients complained of globus sensation were enrolled in this study.

Exclusion criteria

Exclusion criteria: All patients underwent both larygoscopy and upper gastrointestinal endoscopy to exclude organic disease.

Design outcomes

Primary

MeasureTime frame
The subjects werepatients with globus sensation. All patients underwent both larygoscopy and upper gastrointestinal endoscopy to exclude organic disease. After 4 weeks of treatment with rabeprazole sodium (20 mg daily), the patients were divided into PPI-responsive and PPI-resistant groups. Then we investigated oesophageal motility in the PPI-resistant group by a multichannel intraluminal impedance and manometry study.—

Countries

Japan

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026