esophageal cancer
Conditions
Interventions
Chemotherapy using docetaxel+Cisplatin+5-FU Surgical resection
Sponsors
Second Department of Surgery, Wakayama Medical University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1)Patients who are going to undergo curative esophagectomy with 2F or 3F lymph node dissection 2)TNM stage II/III 3)ECOG performance status 0-1 4)20 years and older, 75 years and younger 5)Patients must have histologic confirmation of the diagnosis with tumor 6)Patients have not received prior chemotherapy nor chemoradiotherapy 7)Laboratory values as follows; 3000/mm3 < WBC < 12000/mm3 1500/mm3 < granulocyte count 8.0 gm/dl < hemoglobin Platelet count > 100000/mm3 Aspartate transaminase < 150 IU/L Alanine transaminase < 150 IU/L Creatinine < 1.5 mg/dl 8)Able and willing to give valid written informed consent
Exclusion criteria
Exclusion criteria: Different histological type from squamous cell carcinoma or adenocarcinoma Patient with allergic response to anticancer drugs (docetaxel, cisplatin, 5-FU) Active or uncontrolled infection Pregnancy (women of childbearing potential: refusal or inability to use effective means of contraception) Clinically significant heart disease Patients with a history of myocardial infarction within the previous three months Patients with uncontrolled diabetes mellitus or hypertension Patients with interstitial pneumonia or pulmonary fibrosis Patients who receive hemodialysis Presence of clinically apparent central nervous system metastases Patients with any other severe concurrent disease, which in the judgment of the investigator, would make the patient inappropriate for entry into this study Decision of unsuitableness by principal investigator or physician-in-charge
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pathological response | — |
Secondary
| Measure | Time frame |
|---|---|
| Curative resection rate Clinical response of chemotherapy Postoperative complication 2y survival rate 3y survival rate | — |
Countries
Japan
Contacts
Public ContactMakoto Iwahashi
Wakayama Medical University Second Department of Surgery
Outcome results
None listed