The efficacy of oral conbination administration of tranilast and steroid for the prevention of esophageal stricture after ESD

The efficacy of oral conbination administration of tranilast and steroid for the prevention of esophageal stricture after ESD - The randomised controlled trial of oral administration of tranilast and steroid for preventing esophageal stricture after ESD

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000007337

Enrollment

Registered

2012-02-20

Start date

2010-11-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

subcircunferentialand circumferential esophageal sqamous cell carcinoma

Interventions

combinative administration of tranilast and steroid for 6 weeks after ESD combinative administration of placebo and steroid for 6 weeks after ESD

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: patients suffering from superficial esophageal sqaumoua cell carcinoma whose circumference are more than 3/4 by endoscopic examination with lugor spray

Exclusion criteria

Exclusion criteria: patients with contraindication of medication, having severe complication, having had previous treatment of CRT/RT or operation for cervical or thracic or upper abdominal diseases, having medication which might affect the effect of tranilast or steroid

Design outcomes

Secondary

Measure	Time frame
The number of endoscopic balloon dilation for treating esophageal stricture, The symptomatic scoring of dysphagia	—

Primary

Measure	Time frame
The rate of esophageal stricture after circumferential or subsircunferential ESD	—

Countries

Japan

Contacts

Public ContactKatsunori Iijima

Tohoku University Division of Gastroenterology

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026