Influence of paraoxonase 3 on pharmacokinetics of simvastatin in healthy volunteers

Influence of paraoxonase 3 on pharmacokinetics of simvastatin in healthy volunteers - Relationships between simvastatin PK and PON3 activity

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000007295

Enrollment

100

Registered

2012-03-01

Start date

2012-03-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Healthy volunteers

Interventions

For in vitro assay, participants are taken a blood sampling under an overnight fasting. As to a clinical trial, on the day 1, subjects are administered single 10 mg of simvastatin orally, and undergo

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Healthy adults

Exclusion criteria

Exclusion criteria: Smoker

Design outcomes

Primary

Measure	Time frame
Serum paraoxonase-3 activity Serum paraoxonase-3 concentration Plasma concentrations of simvastatin Plasma concentrations of midazolam	—

Countries

Japan

Contacts

Public ContactShingen Misaka

Fukushima Medical University School of Medicine, Department of Pharmacology

misaka@fmu.ac.jp+81-24-548-2111

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026