a multi-center, phaseII, prospective randomized study to investigate optimal duration of prophylactic antimicrobial agent in patients who undergo pancreatico-duodenectomy following preoperative biliary drainage

a multi-center, phaseII, prospective randomized study to investigate optimal duration of prophylactic antimicrobial agent in patients who undergo pancreatico-duodenectomy following preoperative biliary drainage - A prospective study to investigate optimal duration of prophylactic antimicrobial agent in patients who undergo pancreatico-duodenectomy

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000007277

Enrollment

Registered

2012-02-14

Start date

2012-02-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Patients without a symptom of cholangitis who have a planned pancreaticoduodenectomy following preoperative biliary drainage.

Interventions

To administrate 1g of CZOP every 8hours until post-operative day4 To administrate 1g of CZOP every 8hours during pancreaticoduodenectomy

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: A patient without a symptom of cholangitis who have a planned pancreaticoduodenectomy following preoperative biliary drainage

Exclusion criteria

Exclusion criteria: 1. a patient with a symptom of cholangitis after preoperative biliary drainage. 2. a patient with anaerobic bacteria detected after preoperative biliary drainage. 3. a patient with resistant bacteria detected after preoperative biliary drainage. 4. a young patient and a patient who has difficulty in self-decision-making 5. a patient who is inappropriate for study entry by a chief doctor

Design outcomes

Primary

Measure	Time frame
Frequency of surgical site infection	—

Countries

Japan

Contacts

Public ContactSohei SATOI MD

Kansai Medical University Department of Surgery

satoi@hirakata.kmu.ac.jp

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026