Trials of fetoscopic laser surgery for twin twin transfusion during 26 to 27 weeks of gestation

Trials of fetoscopic laser surgery for twin twin transfusion during 26 to 27 weeks of gestation - Fetoscopic laser surgery for TTTS at 26 and 27 weeks

Status

Active, not recruiting

Phases

Phase 1

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000007208

Enrollment

Registered

2012-02-10

Start date

2012-02-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Twin twin transfusion syndrome

Interventions

Fetsocopic laser surgery is performed according to the procedure for twin to twin transfusion syndrome. The anastomoses between the twins are coagulated by laser under fetoscopy through the maternal

Eligibility

Sex/Gender

Female

Inclusion criteria

Inclusion criteria: 1) Between 26 and 27 weeks of gestation 2) Monochorionic diamniotic twin pregnancy 3) Ultrasound findings before surgery meet the criteria as described following i. TTTS (MVP > 10 cm in one twin, and MVP < 2 cm in another twin) ii. No presence of fetal anomaies 4) No sign of pregnancy induced hypertension 5) No genital bleeding 6) No premature rupture of membrane 7) Greater than or equal to 20 mm of cervical length

Exclusion criteria

Exclusion criteria: 1) Pregnant woman needs treatment for infectious disease. 2) Presence of HIV antibody, HCV antibody, or HBe antigen in pregnant women 3) Pregnant woman needs treatment for psychological problems 4) American Society of Anesthesiology (ASA) Physical Status Classification: Class 3, 4, 5, or 6

Design outcomes

Primary

Measure	Time frame
Completion of laser surgery and surgery for pregnant women	—

Secondary

Measure	Time frame
Improvement of TTTS at 14 days after surgery, Complications of laser surgery until 14 days laser surgery	—

Countries

Japan

Contacts

Public ContactMasahiko Nakata MD PhD

Kawasaki Medical School Department of Obstetrics and Gynecology2

nakata@med.kawasaki-m.ac.jp086-225-2111

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026