Hypertension
Conditions
Interventions
None listed
Sponsors
Southern Heart Conference
Eligibility
Sex/Gender
Male
Inclusion criteria
Inclusion criteria: 1) Patients with essential hypertension, who have been previously treated with antihypertensive drugs including ARB for more than 3 months, however, the target blood pressure defined by the guideline for treatment of hypertension has not been achieved 2) Patiens aged 20 to 79 years at the time of the first visit 3) Outpatients 4) Patients who have given written informed consent on use of theie data for the study
Exclusion criteria
Exclusion criteria: 1) Patients with secondary hypertension 2) Patients with cardiac insufficiency (more than NYHA grade II) 3) Patients under treatment with thiazide diuretic 4) Pregnant patients including one trying to conceive pregnancy during the planned study period 5) Patients with severe liver dysfunction 6) Patients with renal failure (serum creatinine ≥2.0 mg/dL) 7) Patients with a history of hypersensitivity to ingredients of losartan and hydrochlorothiazide 8) Patients with a history of hypersensitivity to thiazide or thiazide-like diuretics 9) Patients who are considered not eligible for the study by the attending doctor due to medical reasons
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change and % change in BNP after 12 months of treatment | — |
Secondary
| Measure | Time frame |
|---|---|
| Change and % change in blood pressure after 1,2,3,6,9,12,18,24,30 and 36 months of treatment Change and % change in Uric acid, HbA1c, HDL-C, BNP (excluding values at 12 months), Echocardiography, Electrocardiogram after 3,12,24,30 and 36 months of treatment | — |
Countries
Japan
Contacts
Public ContactHiroshi Meno
Southern Heart Conference secretariat Southern Heart Conference secretariat
Outcome results
None listed