The effect of Rho kinase inhibitor for the prevention of post-keratoplasty corneal endothelial cell loss

The effect of Rho kinase inhibitor for the prevention of post-keratoplasty corneal endothelial cell loss - The effect of Rho kinase inhibitor for the prevention of post-keratoplasty corneal endothelial cell loss

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000007082

Enrollment

Registered

2012-02-01

Start date

2012-02-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Post-keratoplasty corneal endothelial cell loss

Interventions

Administration of Rho kinase inhibitor eye drops Administration of vehicle

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Post keratoplasty 2. Obtainment of prior written informed consent

Exclusion criteria

Exclusion criteria: 1. Pregnant or breast-feeding women 2. Patients with a psychological disorder or who could not comprehend instructions from the physician 3. Other criteria deemed improper for inclusion

Design outcomes

Primary

Measure	Time frame
Corneal endothelial cell density	—

Countries

Japan

Contacts

Public ContactNaoki Okumura

Kyoto Prefectural University of Medicine Department of Ophthalmology

nokumura@koto.kpu-m.ac.jp075-251-5578

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026