Effect of single dose administration of trichlormethiazide on the serum level and clearance of uric acid: open-label controlled dose-escalating trial with healthy Japanese male volunteers

Effect of single dose administration of trichlormethiazide on the serum level and clearance of uric acid: open-label controlled dose-escalating trial with healthy Japanese male volunteers - Effect of single dose administration of trichlormethiazide on the serum level and clearance of uric acid

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000007013

Enrollment

Registered

2012-01-04

Start date

2012-01-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

hyperuricemia

Interventions

no treatment trichlormethiazide 2 mg trichlormethiazide 4 mg trichlormethiazide 8 mg

Eligibility

Sex/Gender

Male

Inclusion criteria

Inclusion criteria: Healthy Japanese male volunteers (20-39 years old)

Exclusion criteria

Exclusion criteria: 1. Disease that should be treated 2. On medical treatment 3. History of cardiovascular disease 4. Liver disease (AST >40 or ALT >40) 5. Kidney disease (serum creatinine >1.2 mg/dL) 6. Serum uric acid level >7.0 mg/dL 7. Serum electrolyte abnormality 8. Hematocrit >50% 9. Allergic reaction to thiazide and its related diuretics 10. Systolic blood pressure <90 mmHg or >140 mmHg 11. Body weight <40 kg or >90 kg 12. Not appropriate to this study by other reasons

Design outcomes

Primary

Measure	Time frame
Changes in the serum uric acid level and uric acid clearance by single dose administration of trichlormethiazide	—

Secondary

Measure	Time frame
Relation between the polymorphisms of MRP4 and the serum uric acid level or uric acid clearance	—

Countries

Japan

Contacts

Public ContactTatsuya Yoshihara

Faculty of Medical Sciences, Kyushu University Department of Clinical Pharmacology

tatsuya@clipharm.med.kyushu-u.ac.jp+81-92-642-6082

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026