Stroke Acute Management with Urgent Risk-factor Assessment and Improvement (SAMURAI) study on anticoagulant therapy in nonvalvular atrial fibrillation (NVAF)

Stroke Acute Management with Urgent Risk-factor Assessment and Improvement (SAMURAI) study on anticoagulant therapy in nonvalvular atrial fibrillation (NVAF) - SAMURAI-NVAF Study

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000006930

Enrollment

1000

Registered

2011-12-22

Start date

2011-09-21

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Ischemic stroke

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Consecutive acute ischemic stroke/TIA patients with NVAF who begin to receive anticoagulant therapy within 7 days after stroke onset

Exclusion criteria

Exclusion criteria: 1.Rheumatic mitral valve disease 2.A history of prosthetic valve replacement or mitral valve surgical repair 3.Active infective endocarditis 4.Patient, family member or legally responsible person does not have given informed consent 5.Inappropriate patient's conditions for study enrollment in the opinion of the investigator

Design outcomes

Primary

Measure	Time frame
1.Ischemic stroke recurrence, systemic embolism and major hemorrhage during acute hospitalization or within the initial 30 days 2.Ischemic stroke recurrence, systemic embolism and major hemorrhage within 2 years. Vital and functional outcomes assessed by the modified Rankin Scale within observation period/modified Rakin scale at 3 months, 1 year, and 2 years after stroke	—

Secondary

Measure	Time frame
1.Ischemic event(ischemic stroke recurrence, revacularization, systemic embolism, ACS/PCI, DVT/PTE) 2.Hemorrhagic event(major hemorrhage, severe GI bleeding, transfusion) 3.Withdrawal of the anticoagulant therapy	—

Countries

Japan

Contacts

Public ContactKazunori Toyoda

National Cerebral and Cardiovascular Center Department of Cerebrovascular Medicine

toyoda@hsp.ncvc.go.jp06-6170-1070

Outcome results