Relationship between activity in heme oxygenase-1 (HO-1) and risk factors for cardiovascular diseases in patients with obstructive sleep apnea (OSA)

Relationship between activity in heme oxygenase-1 (HO-1) and risk factors for cardiovascular diseases in patients with obstructive sleep apnea (OSA) - Relationship between activity in heme oxygenase-1 (HO-1) and risk factors for cardiovascular diseases in patients with obstructive sleep apnea (OSA)

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000006924

Enrollment

Registered

2011-12-21

Start date

2012-01-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Obstructive sleep apnea syndrome

Interventions

Continuous positive airway pressure

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients for polysomnography with suspected OSA

Exclusion criteria

Exclusion criteria: *Smoker *Patients with smoking history within 6 months *Patients with chronic pulmonary disease (Bronchial asthma, chronic obstructive pulmonary disease (COPD), interstitial pneumonia, etc) *Patients under treatment for acute infection disease or malignant disease *Patients who cannot take a meal tolerance test

Design outcomes

Primary

Measure	Time frame
The correlation between changes in fraction of carbon monoxide (CO) during sleep and degrees of vascular endothelial dysfunction, intima media thickness, glucose intolerance, heart function, and proBNP	—

Secondary

Measure	Time frame
Association between severity of obstructive sleep apnea (OSA) and fraction of CO, vascular endothelial dysfunction, glucose intolerance, postprandial lipid metabolism, heart function, proBNP, and serum and urinary biomarkers Changes in fraction of CO, vascular endothelial dysfunction, glucose intolerance, postprandial lipid metabolism, heart function, proBNP, and serum and urinary biomarkers in patients with OSA before and after CPAP treatment	—

Measure

Time frame

Association between severity of obstructive sleep apnea (OSA) and fraction of CO, vascular endothelial dysfunction, glucose intolerance, postprandial lipid metabolism, heart function, proBNP, and serum and urinary biomarkers Changes in fraction of CO, vascular endothelial dysfunction, glucose intolerance, postprandial lipid metabolism, heart function, proBNP, and serum and urinary biomarkers in patients with OSA before and after CPAP treatment

—

Countries

Japan

Contacts

Public ContactMasanori Azuma

Kyoto University Graduate School of Medicine Departmet of Respiratory Medicine

mazu@kuhp.kyoto-u.ac.jp075-751-3852

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026