Effect of nifedipine CR on blood pressure and renal function in CKD patients versus Cilnidipine

Effect of nifedipine CR on blood pressure and renal function in CKD patients versus Cilnidipine - Effect of nifedipine CR on blood pressure and renal function in CKD patients versus Cilnidipine

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000006854

Enrollment

Registered

2011-12-07

Start date

2011-12-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

chronic kidney disease, hypertension

Interventions

Nifedipine CR group: In the intervention phase, add-on combination therapy will be performed by nifedipine CR 40-60mg daily for 24 weeks . Cilinidipine group: In the intervention phase, add-on com

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1) Chronic kidney disease stage 3 and 4 2) On ARB-based combination therapy with CCB amlodipine 3) Clinic SBP : <150mmHg and >= 130 mmHg, or clinic DBP: <100mmHg and >=80 mmHg.

Exclusion criteria

Exclusion criteria: 1) Secondary hypertension 2) Diabetic nephropathy 3) Schedule of dialysis induction within one year 4) Cardiac shock 5) Pregnant or suspicious women. 6) History of hypersensitivity to nifedipine or cilinidipine. 7) Judged as inappropriate for the study

Design outcomes

Primary

Measure	Time frame
1.clinic BP 2.urinary albumin excretion	—

Countries

Japan

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026