Non-squamous,non-small-cell lung cancer
Conditions
Interventions
CBDCA AUC6(day1)+Pemetrexed 500mg/m2(day1)+Bevacizumab 15mg/kg(day1) q3weeks x2cycles CBDCA AUC6(day1)+ Pemetrexed 500mg/m2 (day1) q3weeks x1cycles Surgical operation is performed over 3 weeks
Sponsors
University of Tsukuba, Faculty of Medicine, Department of Thoracic Surgery
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1)Histologically or cytologically proven non-squamous non small cell lung cancer 2)Patients with StageII(exclusing N0)/III 3)Without previously treatment for lung cancer 4)ECOG Performance status 0-1 5)Age:20 years to less than 75 years 6)Patients who has measurable by RECIST(ver 1.1)criteria 7)Adequate organ function 8)Life expectancy more than 3 months 9)Signed written informed consent
Exclusion criteria
Exclusion criteria: 1)Uncontrolled infection or Serious medical complications 2)Uncontrollable diabetes mellitus 3)Uncontrollable hypertension 4)Therapeutic anticoagulopathy (except Aspirin within 325mg/day) 5)Current or previous history of hemoptysis 6)Evidence of bleeding diathesis or hemoptysis 7)With great vessel invasion 8)Cavity in tumor 9)Uncontrollable gastrointestinal ulceration 10)Current or previous(within the last 1 year) history of GI perforration 11)History of severe heart disease 12)Interstitial pneumonia or pulmonary fibrosis detectableon chest X-ray 13)Multiple primary cancer 14)With a history of drug sensitivity 15)Patients who do not want to take vitamin preparation 16)Serious psychiatric illness or psychological symptom 17)Women who are pregnant, lactating or with childbearing potential 18)Ineligible based on decision of an investigator.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Down staging rate | — |
Secondary
| Measure | Time frame |
|---|---|
| 2year survival rate,2-years relapse free survival,Progression free survival,rate of completion of the protocol treatment,Pathologic complete response rate,Complete resection rate,Safety | — |
Countries
Japan
Contacts
Public ContactYukio Sato
University of Tsukuba Faculty of Medicine, Department of Thoracic Surgery
Outcome results
None listed