Randomized controlled trial to examine the efficacy of late evening snack for advanced hepatocellular carcinoma.

Randomized controlled trial to examine the efficacy of late evening snack for advanced hepatocellular carcinoma. - Randomized controlled trial to examine the efficacy of late evening snack for advanced hepatocellular carcinoma.

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000006751

Enrollment

Registered

2011-11-21

Start date

2011-11-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

hepatocellular carcinoma

Interventions

Dietary advice and one package of Aminoleban EN as LES before sleep for LES group. Dietary advice only for control group.

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Unresectable hepatocellular carcinoma

Exclusion criteria

Exclusion criteria: 1)hepatocellular carcinoma rupture 2)more than 3mg/L of total bilirubin level 3)uncontrollable ascites 4)more than 2mg/L of serum creatinine level 5)history of hepatic coma within a month 6)allergy for milk (contraindication of Aminoleban EN)

Design outcomes

Primary

Measure	Time frame
Onset rate of life-threatening event (liver failure, esophagogastric varix rupture, tumor rupture, liver-related death).	—

Secondary

Measure	Time frame
Change of QOL, subjective symptoms, an examination for blood biochemistry, the physical measured value	—

Countries

Japan

Contacts

Public ContactShinpei Sato

Kyoundo Hospital gastroenterology and hepatology

sato-sinpei@umin.ac.jp03-3292-2051

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026