Corneal epithelial stem cell deficiency
Conditions
Interventions
Harvest of the oral mucosal tissue is conducted at the central operation room or the operation room of the outpatient unit of department of ophthalmology in Tohoku University Hospital. The safety of h
Sponsors
Department of Ophthalmology, Tohoku University Graduate School of Medicine
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) Total limbal stem cell deficiency 2) Entire corneal surface is covered by conjunctival tissue 3) Regardless of gender, and must be over 20 years old when the subjects agree with this project 4) The signed consent is required at least one eye have to fully meet the criteria
Exclusion criteria
Exclusion criteria: 1) Subjects who are pregnant, plan to become pregnant, or are breast-feeding. 2) Subjects who have systemic infections (HBV, HCV, HIV, HTLV-1) 3) Subjects who have extremely severe dry eye 4) Subjects who have extensive oral mucosal scarring and impossibile to obtain the oral mucosal tissue. 5) Subjects whose performance status is scored over 3 points. 6) Subjects who are not unsuitable for this project by some complications (judged by the docter in charge).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To evaluate a size of epithelial defect and conjunctivalized corneal surface area in first postoperative year. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Improved visual acuity 2. Improved corneal opacity 3. Improved corneal neovascularization 4. Expected eye complications 5. All adverse events | — |
Countries
Japan
Contacts
Public ContactShunji Yokokura
Tohoku University Graduate School of Medicine Department of Ophthalmology
Outcome results
None listed