aspiration pneumonia
Conditions
Interventions
Administration of liquid nutrients for 7 days followed by semi-solid nutrients for 7 days
Administration of semi-solid nutrients for 7 days followed by solid nutrients for 7 days
Sponsors
Kitano Hospital, The Tazuke Kofukai Medical Research Institute
Nishi Kyoto Hospital Intensive Care Home for the Elderly ,Yorokobien
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: (1)At least 2 weeks have passed after gastrostomy. (2)Patients required tube-feeding in hospital setting (3)Patients with correctable dehydration by the time of enrollment if they have. (4)Patients over 20 years-old and who have given written informed consent by themselves or their representative (5)Regardless of gender
Exclusion criteria
Exclusion criteria: (1) Patients with diseases that affect salivation such as Sjogren's syndrome, sialoadenitis, salivary gland cancer (2) Patients with remarkably decreased salivation(patients with less than 0.05g in 30 seconds assessed by the cotton methods) (3) Patients with severe infection of gastrostomy site (4) Patients with active aspiration pneumonitis (5) Patients who can take food orally (6) Patients with ileus or no residual intestinal function (7) Patients who have not undergone neither oral feeding nor tube feeding over 30 days (8) Patients with severe liver disorder(AST or ALT 2.5 times higher than upper normal limit of the institution) (9) Patients with poor control of diabetes mellitus(HbA1C > 8.0%) (10) Patients with renal dysfunction(Cre > 2.0mg/dl) (11) Patients with allergy to any ingredients of the enteral formula (12) Patients who were judged as inappropriate to enroll clinical study by physicians
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To compare the change of salivary secretion after administration of liquid or semi-solid enteral nurtients | — |
Secondary
| Measure | Time frame |
|---|---|
| To measure pH of saliva and to evaluate status of gastroesophageal reflux | — |
Countries
Japan
Contacts
Public ContactManabu Ishitoko,M.D.
Kitano Hospital, The Tazuke Kofukai Medical Research Institute Respiratory Disease Center
Outcome results
None listed