Patients with salt sensitive hypertension and LDL hyperlipemia
Conditions
Interventions
A salt restricted diet for three days is given to the patient under 5 mg of amlodipine administration. Then 10mg of atorvastatin added, a salt restricted diet for three days is given to the patient.
Sponsors
Kyoto University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) hypertension (systoric BP>140mmHg or diastoric BP>90mmHg) 2) hyper LDL-C (>120mg/dl) without statin treatment 3) serum Cr < 3.0mg/dl 4) over 20 years old 5) obtain written informed consent.
Exclusion criteria
Exclusion criteria: 1) a patient who is treated with diuretics. 2) a patient who is treated with statins. 3) poor controlled hypertension (systoric BP>180mmHg or diastoric BP>110mmHg) 4) patient with heavy cardiovascular disease 5) hepatitis (ALT over three folds increase by normal limits) 6) pregnancy, child bearing potential pre- or nursing 7) uncontrolled arrhythmia 8) inadequate due to other reason by attending physician's judgments 9) history of hypersensitivity to atorvastatin
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| pressure-diuresis curve | — |
Secondary
| Measure | Time frame |
|---|---|
| changes in value of the following data from baseline to the end of examination(Blood Pressure, Urine volume, urinary sodium concentration, urinary potasium concentration, urinary neutrophil gelatinase associated lipocalin2 (NGAL) consentration, urinary 8OH-dG concentration, total cholesterol, low density lipoprotein, triglyceride, high density lipoprotein, high sensitive C-reactive protein, serum Urea, serum creatinine, serum Na,K,Cl, plasma renin activity, plasma aldosterone concentration ) | — |
Countries
Japan
Contacts
Public ContactMasato KASAHARA
Kyoto University Hospital Institute for Advancement of Clinical and Translational Science (iACT)
Outcome results
None listed