thoracotomy
Conditions
Interventions
treatment group (Pregabalin group)
control group (NSAID group)
Sponsors
Teikyo University, School of Medicine, Department of Surgery
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: (1) patients who are ages 20-70 (2) patients who are PS 0, 1 (ECOG) (3) patients who undergo respiratory surgery that requires intercostal manipulation (4) patients who have normal kidney function with creatinine clearance >30ml/min (5) patients who have signed the consent form to participate in this study
Exclusion criteria
Exclusion criteria: (1) patients who have been taking antidepressants, anticonvulsant, opoids, and NSAIDs before surgery (2) patients who have serious complications (such as uncontrollable heart, lung, liver or kidney disease, and diabetes) (3) patients who have a history of angioedema (4) patients who are pregnant, are nursing, or might be pregnant (voluntary) (5) patients who handle hazardous machinery, such as driving a car (6) patients who are considered unsuitable for the study by the primary physician
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| -Control rate of pain at the incision site after surgery; NRS on the third month after surgery | — |
Secondary
| Measure | Time frame |
|---|---|
| -Control rate of pain at the incision site after surgery; NRS on the first, third, and seventh day after surgery, VAS in the fourth and eighth week after surgery -Control the level of pain according to the type of pain (neurophathic pain or nociceptive pain) - Occurrence rate of adverse event | — |
Countries
Japan
Contacts
Public ContactNoriyuki Matsutani
Teikyo University, School of Medicine Surgery
Outcome results
None listed