Effects of combination drugs of calcium channel blockers and angiotensin II receptor blockers on blood pressure, lipid profile, and glucose metabolism in hypertensive patients with glucose intolerance.

Effects of combination drugs of calcium channel blockers and angiotensin II receptor blockers on blood pressure, lipid profile, and glucose metabolism in hypertensive patients with glucose intolerance. - J-METS test

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000006651

Enrollment

Registered

2011-11-05

Start date

2011-11-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hypertension

Interventions

telmisartan 40mg + amlodipine 5mg candesartan 8mg + amlodipine 5mg

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1 Hypertensive patients treated with 5mg/day of amlodipine who did not achieve the target blood pressure of JHS 2009 criteria. 2 Patients with impaired glucose tolerance(fasting blood suger > 110 mg/dl and HbA1c<6.5 %)

Exclusion criteria

Exclusion criteria: 1 Patients administered renin angiotensin system inhibitors. 2 Patients with a history of changing of medical therapy for blood pressure, lipid and glucose metabolism within three months. 3 Patients under treatment for diabetes. 4 Patients with renal failure.(serum creatinine > 1.5 mg/dL) 5 Patients who are pregnant, possibly pregnant, or lactating.

Design outcomes

Primary

Measure	Time frame
The achievement rate of blood pressure targets measured at home (home BP) and at the outpatient department according to the Japanese Society of Hypertension (JSH) 2009 criteria	—

Secondary

Measure	Time frame
Lipid profile (total cholesterol, HDL- cholesterol, triglyceride, LDL-cholesterol), fasting blood suger, HbA1c, IRI, HOMA-R, adiponectin	—

Countries

Japan

Contacts

Public ContactTakuma Yoshihara

Juntendo University School of Medicine Department of Cardiovascular Medicine

tayosiha@juntendo.ac.jp03-3813-3111

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026