A study of small fiber neuropathy (SFN): immunohistochemical changes of peripheral nerve fibers on biposied skin and correlation with inflammatory cytokine expression

A study of small fiber neuropathy (SFN): immunohistochemical changes of peripheral nerve fibers on biposied skin and correlation with inflammatory cytokine expression - A study of small fiber neuropathy (SFN)

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000006639

Enrollment

Registered

2011-11-01

Start date

2011-11-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

small fiber neuropathy

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients suffered from diabetes mellitus, collagen diseases, vasculitis and sarcoidosis accompanied with subjective symptoms such as chronic pain, dysaesthesia, and/or disturbed temperature sensitivity are to be included. Patients are neurophysiologically and electrophysiologically diagnosed and classified as possessing SFN, or not having SFN but with disturbance of peripheral nerves with greater diameter.

Exclusion criteria

Exclusion criteria: Patients diagnosed as not having SFN or other type of disturbance of peripheral nerves with greater diameter, or patients with disagreement are to be excluded from the study. .

Design outcomes

Primary

Measure	Time frame
Epidermal nerve fiber density Immunohistochemical reactivity alteration in dermal and epidermal nerve fibers Cytokine expression in biopsied skin in protein and mRNA levels	—

Secondary

Measure	Time frame
Morphological change in dermal and epidermal nerve fibers Cytokine expression in the peripheral blood in protein and mRNA levels	—

Countries

Japan

Contacts

Public ContactSeiichi Izaki, MD, PhD

Saitama Medical Center, Saitama Medical University Department of Dermatology

izks1@saitama-med.ac.jp049-228-3652

Outcome results