Effect of parathyroidectomy on serum Klotho and FGF23 levels in hemodialysis patients with severe secondary hyperparathyroidism

Effect of parathyroidectomy on serum Klotho and FGF23 levels in hemodialysis patients with severe secondary hyperparathyroidism - Klotho-PTx study

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000006611

Enrollment

Registered

2011-11-01

Start date

2011-11-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Secondary hyperparathyroidism

Interventions

Parathyroidectomy

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Serum intact PTH >500pg/ml Serum calcium >10.0mg/dl or phosphorus >6.0mg/dl Presence of enlarged parathyroid glands larger than 500mm3

Exclusion criteria

Exclusion criteria: Dialysis vintage less than 3 months

Design outcomes

Primary

Measure	Time frame
Assess the effects on parathyroidectomy on serum Klotho and FGF23 levels	—

Secondary

Measure	Time frame
Changes from baseline in serum calcium, phosphorus, and intact PTH levels	—

Countries

Japan

Contacts

Public ContactHirotaka Komaba

Tokai University School of Medicine Division of Nephrology, Endocrinology and Metabolism

hkomaba@tokai-u.jp0463-93-1121

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026