Dyspnea in cancer patients
Conditions
Interventions
None listed
Sponsors
Central Japan Lung Study Group (CJLSG)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) Primary or metastatic lung cancer 2) Dyspnea at rest 3) Aged 20 years or older 4) Expected to be able to take oral medicine for more than one week 5) Without dementia, impaired consciousness, or delirium 6) Opioid rescue use three times a day or less, No rescue use within four hours 7) Respiratory rate 10/min or more 8) Written informed consent
Exclusion criteria
Exclusion criteria: 1) Clinical condition which can improve with other medication, such as pneumonia or heart failure is predominant. 2) Severe organ disfunction 3) History of serious allergy to morphine 4) Receiving pentazocine or buprenorphine 5) Previous registration history
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Intensity of dyspnea before and after the oral morphine medication: Assessing with Visual Analog Scale (VAS) | — |
Secondary
| Measure | Time frame |
|---|---|
| - Change of VAS in each background including causative disorder, baseline opioid, and intensity of baseline dyspnea - Cancer Dyspnea Scale - Numeric Rating Scale (NRS) - Patient's feeling of improvement - Dyspnea 48 hours after medication - Adverse events, such as respiratory depression, sleepiness, nausea, and constipation | — |
Countries
Japan
Contacts
Public ContactKosuke Takahashi
Aichi Cancer Center Aichi Hospital Department of Respiratory Medicine
Outcome results
None listed