Learning and memory reconsolidation update mechanism in humans with major depressive disorder

Learning and memory reconsolidation update mechanism in humans with major depressive disorder - Reconsolidation update mechanism in humans with depression

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000006552

Enrollment

Registered

2011-11-01

Start date

2012-12-08

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Major Depressive Disorder

Interventions

On the first day, patients with major depressive disorder will undergo the acquisition task. On the second day, they will receive reminder stimuli, and then extinction training will be performed in 10

Eligibility

Sex/Gender

Male

Inclusion criteria

Inclusion criteria: 1) Diagnosis of major depressive disorder according to the DSM-IV 2) 18 years or older of age 3) Being capable to provide informed consent (Healthy controls) 1) Individuals with no psychiatric disorder according to the DSM-IV 2) 18 years or older of age 3) Being capable to provide informed consent

Exclusion criteria

Exclusion criteria: 1) Presence of any unstable physical or neurological disorder 2) Presence of clinical severe depression(>=4 in the item score for inner tension or pessimistic thoughts in the Montgomery-Asberg Depression Scale) or imminent suicidal thought(>=4 in the item score for suicidal thoughts in the MADRS)

Design outcomes

Primary

Measure	Time frame
Skin Conductance Response upon the re-extinction task	—

Countries

Japan

Contacts

Public ContactHiroyuki Uchida

Keio University School of Medicine Department of Neuropsychiatry

mcn41320@biglobe.ne.jp03-3353-1211(62454)

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026