Efficacy of using antimicrobials based on PK/PD principle in the treatment of NHCAP

Efficacy of using antimicrobials based on PK/PD principle in the treatment of NHCAP - Efficacy of using antimicrobials based on PK/PD principle in the treatment of NHCAP

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000006538

Enrollment

100

Registered

2011-10-14

Start date

2011-10-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

NHCAP(HCAP)

Interventions

Group A:using SBT/ABPC 1.5g q6hr Group B:using SBT/ABPC 3.0g q12hr

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Healthcare associated pneumonia (HCAP) Patients who satisfy the criteria at least one item of each of A,B and C A:1 fever(BT>37.0) 2 cough 3 hypoxemia B: 1 Increased white blood cell count (WBC>10000/mm3), stab cells>15%, or decreased white blood cell count (WBC<4500/mm3) 2 Positive CRP 3 X-ray examination or CT scan of the chest reveal new infiltrative shadows C:Patients who were admitted to nursing homes, care/rehabilitation facilities or health/care facilities for recuperation (for more than 48 hours) ,or who were hospitalized for more than two days for the past 90 days

Exclusion criteria

Exclusion criteria: 1 Patients with renal dysfunction ( Ccr<10ml/min ) 2 Immunocompromised patients or patients receiving immunosuppressive agents 3 Patients whose pneumonia could not be treated by SBT/ABPC 4 Patients with hypersensitivity to SBT/ABPC 5 Patients who were not considered as participant by attending physician

Design outcomes

Primary

Measure	Time frame
Duration of hospitalization	—

Secondary

Measure	Time frame
Mortality in hospital Clinical effect, days 4 and 7	—

Countries

Japan

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026