Effect of Antibiotic Therapy on Reproductive Outcome in Infertile Patients with Repeated Embryo Implantation Failures and Chronic Endometritis

Effect of Antibiotic Therapy on Reproductive Outcome in Infertile Patients with Repeated Embryo Implantation Failures and Chronic Endometritis - Effect of Antibiotic Therapy on Reproductive Outcome in Infertile Patients with Repeated Embryo Implantation Failures and Chronic Endometritis

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000006536

Enrollment

100

Registered

2011-10-13

Start date

2011-04-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic Endometritis

Interventions

Oral administration of 200mg doxycycline (100mg tablet, twice a day) for 14 days

Eligibility

Sex/Gender

Female

Inclusion criteria

Inclusion criteria: Infertile patients with present illness of chronic endometritis and history of three or more consecutive implantation failures after in vitro fertilization and embryo transfer. Provided written informed consent

Exclusion criteria

Exclusion criteria: Patients with a history of hyper-sensitivity to doxycycline

Design outcomes

Primary

Measure	Time frame
Implantation rate and clinical pregnancy rate	—

Secondary

Measure	Time frame
Ongoing pregnancy rate and biochemical pregnancy rate	—

Countries

Japan

Contacts

Public ContactKotaro Kitaya

Oak Clinic IVF Center

kitaya_k@oakclinic-group.com0643981000

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026