Acromegaly
Conditions
Interventions
With oral administration of sitagliptin, patients take test-meal. Thereafter, blood samples are collected at 0, 15, 30, 60, 90, 120 min.
Sponsors
Department of Medicine II, Hokkaido University Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Patients who have been diagnosed as "acromegaly" regardless of treatment status. Patients who agreed with written consent form, receiving enough information of this study.
Exclusion criteria
Exclusion criteria: Patients who do not agreed with written consent form. Patients who have the diseases, which may affect the result of endocrine tests, such as infectious, hepatic, and renal disorders. Poor controlled diabetic patients, because they are not appropriate for the glucose loading test. Patients who are inappropriate for this study by research director.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Frequency of the paradoxical increase of growth hormone in oral glucose tolerance test. Changes of serum growth hormone levels during intravenous glucose loading test and sitagliptin loading test in the patients with paradoxical growth hormone increase. | — |
Secondary
| Measure | Time frame |
|---|---|
| Changes of serum growth hormone levels in pharmacological loading tests in the patients with or without the paradoxical increase. | — |
Countries
Japan
Contacts
Public ContactNagai, So
Hokkaido University Hospital Department of Medicine II
Outcome results
None listed