Patients with heart failure or ischemic heart disease
Conditions
Interventions
Intervention group: remote ischemic conditioning + standardized treatment. Method: Intermittent arm ischaemia through four cycles of 5-minuites infl ation and 5-minuites defl ation of a blood-pressu
Sponsors
University of Yamanashi
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Patients admitted to University of Yamanashi Hospital and fulfilled with following inclusion criteria. (1) Age; 20 years and older. (2) Male and female. (3) Heartfailure or ischemic heart disease.
Exclusion criteria
Exclusion criteria: Patients are excluded with following exclusion criteria. (1) Patients on Hemodialysis therapy and with blood access on upper arm. (2) Patients with severe complications and malignancy. (3) Patients with decreased blood flow or trauma on upper arm.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| All enrolled patients are prospectively followed up for 5 years or until the occurrence of cardiac events. Cardiac events include cardiac death, hospitalization with heart failure, arrhythmia, non-fatal myocardial infarction, unstable angina required coronary revascularization. | — |
Secondary
| Measure | Time frame |
|---|---|
| Endothelial function of brachial artery (FMD), intima-media thickness (IMT) of carotid arteries, %fractional shortning and %ejection fraction measured by cardiac ultrsaound are evaluated at the enrollment, 1 week, and 1 months after enrollment. Blood sampling are preformed at the enrollment, 1 week and 1 month after enrollment for measurement of inflammatory markers, and angiogenic factors. | — |
Countries
Japan
Contacts
Public ContactTakamitsu Nakamura
University of Yamanashi Internal medicine II
Outcome results
None listed