The research of the effects of synbiotics for critically ill patients

The research of the effects of synbiotics for critically ill patients - The research of the effects of synbiotics for critically ill patients

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000006431

Enrollment

150

Registered

2011-09-29

Start date

2011-09-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

critically ill patients

Interventions

Enteral administration of Bifidobacterium breve strain Yakult, Lactobacillus casei strain Shirota and galactooligosacchrides initiating within 72hrs after admission until initiation of oral intake No

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients with severe sepsis treated with mechanical ventilation Trauma patients treated with mechanical ventilation

Exclusion criteria

Exclusion criteria: Patients who do not receive synbiotics within 72hrs from admission Patients who are inappropriate to perform the present trial

Design outcomes

Primary

Measure	Time frame
Infectious complications including enteritis, ventilator-associated pneumonia and bacteremia within 4 weeks from admission	—

Secondary

Measure	Time frame
1. Mortality within 4 weeks 2. Infectious complications including enteritis, ventilator-associated pneumonia, bacteremia within 8 weeks from admission 3. Fecal bacterial counts and organic acids	—

Countries

Japan

Contacts

Public ContactHiroshi Ogura

Osaka University Graduate School of Medicine Department of Trauma and Acute Critical Medicine

ogura@hp-emerg.med.osaka-u.ac.jp81-6-6879-5707

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026