Condition is enough to require surgery under combined general-epidural anesthesia, for example myoma of the uterus, ovarian cyst, denomyosis of the uterus, uterine corpus cancer, uterine cervical cancer, and cancer of ovary et al.
Conditions
Interventions
Control group: They will receive intraoperative IV droperidol and PCEA without droperidol in combination with fentanyl 4 mcg/mL and ropivacaine 0.06%. Before induction of general anesthesia, an epidur
Sponsors
University of Yamanashi Hospital
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: Written informed consent, ASA physical status 1 or 2 female patients scheduled to undergo gynecological surgeries under combined general-epidural anesthesia.
Exclusion criteria
Exclusion criteria: Those have known hypersensitivity to any drugs that is part of this study protocol, contraindications to epidural anesthesia, current opioid use, inability to use the PCEA device, alcohol or narcotic dependence, renal or hepatic insufficiency, QT elongation (QTc interval >450 ms) on preoperative electrocardiogram (ECG) assessment, Parkinsonism, demand premedication, a history of operations under combined general-epidural anesthesia, and a history of severe PONV.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of postoperative nausea and vomiting at each assessment point Complete responder: No vomiting and use of rescue medications within 3 postoperative days | — |
Secondary
| Measure | Time frame |
|---|---|
| Demographic dates, postoperative pain score, need for supplemental analgesics, severity for PONV, times of PONV episodes, use of antiemetics, presence of motor blockade, the sensory block level, postoperative QTc intervals, volume of the study solution, and other adverse events | — |
Countries
Japan
Contacts
Public ContactEmi Nakajima
University of Yamanashi, Faculty of University of Yamanashi Hospital Depatment of Anesthesiology
Outcome results
None listed